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Test Code NTXU NTX-Telopeptide, 24 Hour, Urine

Additional Test Codes

 

Mayo Test ID
NTXPR

 

Reporting Name

NTX-Telopeptide, U

Useful For

1. An adjunct in the diagnosis of medical conditions associated with increased bone turnover

2. The differential diagnosis of osteomalacia versus osteoporosis

3. Identifying individuals with osteoporosis with elevated bone turnover and consequent increased risk for rapid disease progression

4. Prediction of bone densitometry response to antiresorptive therapy of osteoporosis

5. Monitoring and assessing effectiveness of therapy in patients treated for osteopenia, osteoporosis, Paget disease, or other disorders treated with antiresorptive therapy

6. An adjunct in monitoring response to other therapeutic intervention in diseases with increased bone turnover (eg, rickets, osteomalacia, hyperthyroidism)

 

Indications 3 through 5 have been endorsed by the Negotiated Rulemaking Committee of HCFA and are therefore federally reimbursed.

Profile Information

Test ID Reporting Name Available Separately Always Performed
NTXUR NTX-Telopeptide, U No Yes
NTXCT Creatinine, U No Yes

Method Name

NTXUR: VITROS Competitive Chemiluminscence Immunoassay

NTXCT: Enzymatic Colorimetric Assay

Performing Laboratory

Mayo Medical Laboratories in New England

Specimen Type

Urine

Specimen Required

Collection Container/Tube: Clean, plastic urine collection container

Submission Container/Tube: Plastic, 10-mL urine tube (Supply T068)

Specimen Volume: 4 mL

Collection Instructions:

1. Collect urine for 24 hours.

2. No preservative.

3. Refrigerate specimen during collection.

Additional Information:

1. 24-Hour collection is preferred, but second-morning voided or random specimen is also acceptable.

2. See Urine Preservatives in Special Instructions for multiple collections.

Forms: If not ordering electronically, submit a General Request Form (Supply T239) with the specimen.

 

Urine Preservative Collection Options

Ambient

No

Refrigerated

<5 days

Frozen

Preferred

6N HCl

No

50% Acetic Acid

No

Na2CO3

No

Toluene

Yes

6N HNO3

No

Boric Acid

Yes

Thymol

No

Specimen Minimum Volume

2 mL

Specimen Stability Information

Specimen Type Temperature Time
Urine Frozen (preferred) 30 days
  Refrigerated  5 days

Reject Due To

Hemolysis

NA

Lipemia

NA

Icterus

NA

Other

Specimen with pH <5

Special Instructions

Reference Values

All units are reported in nmol Bone Collagen Equivalents/mmol creatinine.

 

Males

<6 years: 576-1,763

6-13 years: 307-1,367

14-17 years: 102-1,048

≥18 years: 21-66

Females

<6 years: 576-1,763

6-13 years: 307-1,367

14-17 years: 55-378

≥18 years: 19-63

 

Values are based on Mayo in-house studies of 75 children and adolescents age 3.5 to 18.5 and >100 adults.

Day(s) and Time(s) Performed

Monday through Friday, varies

CPT Code Information

82523

LOINC Code Information

Result ID Reporting Name LOINC Code
NTXCT Creatinine, U 2161-8
NTX NTX 35334-2
NTXCR NTX-Telopeptide, U 21216-7

Analytic Time

1 day

Test Classification

This test has been cleared or approved by the U.S. Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.